(338) Inhaled lipid nanocarriers for the eradication of pseudomonal biofilms in cystic fibrotic lungs

Introduction: Cystic fibrosis is associated with biofilms of Pseudomonas aeruginosa [1]. P. aeruginosa regulates its virulence via quorum sensing. Alginate plays an essential pathogenic role in P. aeruginosa biofilms [2]. To overcome the stiff sputum and the firm biofilm, an emerging approach is to: (i) apply quorum sensing inhibitors (QSI) to disrupt cell-to-cell communication, biofilm formation and control virulence [3]; (ii) encapsulate QSI in solid lipid nanoparticles (SLNs) to overcome the mucosal barrier; (iii) immobilize alginate lyase (AL) on SLNs to degrade alginate biofilms [4].