(344) Local Extended-Release Colchicine for Intra-Articular Treatment of Gout Flares

Introduction: Gout is a common and very painful form of arthritis, however current gout flares therapies are limited by suboptimal efficacy and safety concerns [1][2]. Oral colchicine, for example, is associated with major systemic side effects that constrain its clinical utility. This highlights a pressing need for safer and more effective therapeutic options. To that end, we developed an intra-articular colchicine dosage form, enhancing efficacy in the joint while avoiding systemic toxicity. This approach is based on extended-release PLGA microspheres tailored for intra-articular injection (Figure 1).