(348) Effective screening of LNP formulations with centrifugal microfluidics devices

Introduction: Lipid nanoparticles (LNPs) have emerged recently as an extremely effective method for delivering nucleic acids to cells for a variety of therapeutic purposes. With 4-5 lipid components each and hundreds of published lipids for incorporation, development of optimized efficacious formulations can be an onerous task. Rapid and inexpensive testing of LNP formulations has largely been accomplished using hand-mixing of the components with a typical laboratory pipette.