(350) Targeting alveolar macrophages with sialic acid-decorated liposomes

Introduction: Pulmonary inflammation is a major cause of lung damage and death. Macrophages, key immune cells in alveoli, polarize from M2 (anti-inflammatory) to M1 (pro-inflammatory) upon pathogen entry. Acetylneuraminic acid (Neu5Ac) is a type of sialic acid found in various organisms, including viruses, is able to be recognized by receptors in certain immune cells, such as macrophages. This study evaluates the internalization and capacity to modulate macrophages polarization by sialic acid-decorated liposomes administered via nebulization in an in vivo LPS-induced inflammation model.