(353) Controlled Release of Gemcitabine with Partially Molecular Imprinted Microspheres for Cancer Therapy

Introduction: Controlled release of drugs is crucial for enhancing therapeutic efficacy especially in anticancer treatments where precise dosing plays a crucial role in patient outcomes. This study introduces partial molecular imprinting (PMI) to control solubility-dependent release by generating nanocavities within a polymer matrix, enhancing drug delivery stability. Although PMI is an emerging concept, its ability to modulate drug crystallinity and release kinetics in biomaterial-based systems shows great promise for advancing targeted cancer therapies and medical technology applications