(356) Rational development of donepezil-curcumin intranasal nanotherapies for Alzheimer’s disease
Introduction: Current Alzheimer’s Disease (AD) treatments mainly manage dementia symptoms, highlighting the pressing need for treatment strategies to retard disease progression. Both donepezil (DPZ) and curcumin (CUR) have neuroprotective effects for AD [1, 2] , co-delivery of which may synergistically improve the therapeutic efficacy. Intranasal nanotherapy enhances treatment efficacy by prolonging drug residence time, increasing cellular internalization, and improving bioavailability [1]. This project aims to produce intranasal nanoparticle-based DPZ-CUR dry powder formulations with Box-Behnken design.
Learning Objectives:
Optimize a DPZ-CUR nanosuspension suitable for intranasal delivery by a quality-by-design approach.
Fabricate intranasal DPZ-CUR nanoagglomerate and nano-embedded dry powders through spray drying.
Evaluate and compare the therapeutic potential of DPZ-CUR dry powder formulations for AD management.
