(370) Lyophilization approach to improve long-term stability of LGA-PEI nanoparticles for drug delivery
Introduction: Polymer-based nanoparticles offer a promising platform for nucleic acid delivery; however, their clinical application is often hindered by storage instability, limiting their therapeutic potential1,2. Lactic-co-glycolic acid-polyethylenimine (LGA-PEI)-based nanoparticles (LPNPs) demonstrate high transfection efficiency with low toxicity in vitro while ensuring robust delivery and safety in vivo3,4. This study evaluates a lyophilization strategy to enhance LPNP stability, addressing key storage challenges and improving their functionality, viability, and applicability in nucleic acid delivery
Learning Objectives:
Evaluate key factors influencing the stability of delivery systems for therapeutic applications.
Compare different strategies for enhancing the long-term stability of nanoparticle formulations.
Assess the impact of storage conditions on nanoparticles using advanced characterization techniques.
