(375) Exploring the Impact of Iron Availability on Antibiotic Resistance in Mycobacterium Species

Introduction: "Iron is vital for the survival and pathogenesis of Mycobacterium tuberculosis (Mtb), which causes tuberculosis (TB). It supports respiration, DNA synthesis, and metabolism. Mtb adapts to iron scarcity by producing siderophores, using transporters, and storing iron in proteins like bacterioferritin [1]. Iron availability impacts Mtb’s virulence, growth, and antibiotic resistance. Our lab is developing Metal-Organic Frameworks (MOFs) for controlled iron delivery to manipulate Mtb’s iron balance, offering potential TB treatments."