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Nanomedicine and Nanoscale Delivery (Focus Group - NND)

(376) Design and Screening of Ionizable Lipids for Precision mRNA Delivery to Extrahepatic Organs

Introduction: Lipid nanoparticles (LNPs) have emerged as the leading platform for nucleic acid delivery, but their tendency to accumulate in the liver limits broader therapeutic applications. While apolipoprotein E (ApoE)-mediated uptake drives liver accumulation, expanding LNP biodistribution to extrahepatic tissues could increase the clinical potential of mRNA-based therapies. This study explores how structural modifications in ionizable lipids (ILs) influence protein corona formation and organ-specific targeting, aiming to develop LNPs capable of selective delivery to the lungs and spleen.

Learning Objectives:

  • Upon completion, participants will be able to describe how lipid structure affects organ targeting.
  • Upon completion, participants will be able to explain how protein corona drives LNP biodistribution.
  • Upon completion, participants will be able to find strategies to enhance extrahepatic mRNA delivery.