(383) Physically Crosslinked Nanocomposite Hydrogels for Sustained Subcutaneous Delivery of Peptides
Introduction: Therapeutic peptides are recognised for their high selectivity, potency, and low toxicity. However, their clinical application is limited by their pharmacokinetic (i.e. low permeability, short half-lives). Chemical modification strategies have improved peptide pharmacokinetics, resulting in several marketed drugs with once-weekly dosing. Formulation strategies have been explored to extend dosing intervals and develop controlled-release systems for subcutaneous delivery. This work investigated polymeric-nanoparticle hydrogels for the loading and sustained delivery of a lipidated GLP-1 analogue.
Learning Objectives:
Fabricate and characterise polymeric nanoparticle hydrogels loaded with a lipidated GLP-1 analogue.
