(385) Impact of nanomaterials on the anti-Candida activity of cysteine-modified amidated decoralin
Introduction: Candidiasis remains an important healthcare challenge exacerbated over the past few years by emerging antifungal drug resistance [1]. Hence, developing new antifungal agents is urgently needed [2]. Amidated decoralin (Dec-CONH₂), a short cationic peptide, exhibits considerable anti-Candida activity but also presents inherent toxicity to mammal cells [3]. Its association with nanomaterials could be an interesting approach for enhancing efficacy while mitigating cytotoxicity, thus providing an alternative to the treatment of candidiasis.
Learning Objectives:
Understand the importance of screening the interactions between nanomaterials and Cys-Dec-CONH₂.
Analyze the impact of biomacromolecules on the efficacy of Cys-Dec-CONH₂.
Evaluate the influence of conjugating Cys-Dec-CONH₂ with nanomaterials on its biological activity.
