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Nanomedicine and Nanoscale Delivery (Focus Group - NND)

(387) Polymer-lipid hybrid nanoparticles for sonographic monitoring of subcutaneous fat reduction

Introduction:

Excess adipose tissue poses both health and aesthetic concerns, driving the demand for non-invasive fat reduction. Traditional approaches like liposuction and cryolipolysis have inherent limitations. Polymer-lipid hybrid nanoparticles (PLN) offer a promising alternative by leveraging lipid metabolism to enhance cellular targeting. Moreover, fatty acid (FA) actively participates in adipocyte metabolism. We propose FA-modified PLNs for generating carbon dioxide gas (COâ‚‚) for local fat reduction while enabling monitoring of nanoparticle activity within adipose tissue through ultrasound imaging.

Learning Objectives:

  • Efficient delivery of through active fatty acid consumption mechanism of adipocyte.
  • Gas-generating PLNs make it possible to monitor nanoparticle activity by sonography.
Hye Won Lee – Master, Hanyang University; Eun Ju Jeong – Ph.D, Supernova Bio; Kuen Yong Lee – Ph.D, Hanyang University

    Poster Presenter(s)

  • In Young Lee

    Ph.D. candidate
    Hanyang university, Seoul-t'ukpyolsi, Republic of Korea