(396) Development an injectable in situ formulation of targeted liposomal cisplatin for chemoradiotherapy

Radiotherapy is effective for oral cancer treatment but may cause side effects and radiation resistance in cancer cells (1). To enhance efficacy, new radiosensitizers have been developed, though issues with non-specificity and low bioavailability persist (2). In this study, glucosamine-cholesterol-based liposomes encapsulating cisplatin and ceramide were prepared and injected in situ into tumors, combined with radiotherapy. This approach proposes a novel chemo-radiotherapy strategy.