(403) Nicotinamide-loaded Peptoid Nanotubes for Energy Regeneration in Brain Injury

Introduction: Acute brain injuries such as perinatal asphyxia, stroke, and traumatic brain injury result in pathology that depletes ATP. Nicotinamide adenine dinucleotide (NAD+), a key regulator of cellular homeostasis, is crucial for ATP production and DNA repair in post-injury recovery. However, the therapeutic potential of NAD+ and its precursors, such as nicotinamide (NAM), is limited by the complexity of their metabolic pathways and challenges in effective intracellular delivery. Therefore, cellular delivery strategies are needed to capture the potential of an NAD+-regenerating therapeutic approach.