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Ocular Delivery (Focus Group - OcD)

(432) Mucoadhesive micelle for anterior segment ocular drug delivery

Introduction: Eye drops are widely accepted despite clearance mechanisms such as drug dilution, high turnover rate of the aqueous tear film, and drainage via the nasolacrimal duct leaving only 5% of the applied therapeutic to reach its target tissue.[1] A polymer-based micelle was formulated with a mucoadhesive moiety that interacts with the mucin layer of the tear film, reducing clearance.[2] This polymer exhibits PH sensitivity, reducing drug compatibility. A reformulation with reduced PH sensitivity may broaden drug compatibility while maintaining mucoadhesive properties.

Learning Objectives:

  • To develop a polymeric delivery system that interacts with the ocular surface to sustain delivery.
  • The system should be able to be formulated with various therapeutics.
  • The system should show compatibility with tissues associated with the anterior surface of the eye.