(440) A dissolvable gel-based in vitro dissolution method for in situ-forming implants

Using intraocular implants to deliver drug to the eye has increased in recent years. Extended-release products like Ozurdex® and Iluvien® provide controlled release of drug for months to years. During development of these long-acting products, in situ-forming implants could serve as a precursor to preformed implants which would allow for drug screening without equipment needed to make a preformed implant. However, there is no standard method for in vitro dissolution of intraocular implants. Here we report the evaluation of a gel-based in vitro dissolution method for in situ-forming implants.