(448) Direct Compression of Co-Processed Mannitol-HPMC for Controlled Release Tablets

Introduction: Controlled release formulations are becoming more popular in the market due to their ability to release drug into the system at a determined rate. Managing the drug release profile allows formulators to set the dosing to provide a steady and predictable treatment over longer times than immediate release formulations, reducing dosages per day without losing therapeutic effects. Having controlled release excipients that are direct compressible allows for oral dosage tablets to be easily made without the time needed to process the material before compression.