(450) Klucel™ Xtend hydroxypropylcellulose (HPC) for Dual Active Diabetic Controlled Release Dosages

Introduction: Dual-active controlled-release formulations for Type II diabetes provide several benefits, including reduced dosing frequency, and improved patient compliance. Hydroxypropyl Methylcellulose (HPMC) usually comprise 20-30% of the weight of a tablet to achieve an acceptable release profile. This can result in large, hard-to-swallow tablets with complex processing. This study evaluates the process versatility and the tablet size reduction of the Klucel™ Xtend HPC to match the release profiles of a bi-layer dosage of dual diabetic drugs.