Skip to main content
CRS 2025 Annual Meeting & Exposition Main banner
Rate Poster

Oral Delivery (Focus Group - OrD)

(454) Development of pH-responsive Hydrogel in Gastro-Resistant Capsules for Colon Targeted Drug Delivery

Introduction: Colon-targeted drug delivery systems are a promising strategy for improved treatment of local diseases affecting the colon, such as inflammatory bowel disease (IBD). IBD is associated with significant patient morbidity with more than 6.8 million patients globally suffering from IBD complications [1]. The physiology of the gastrointestinal tract (GIT), which has a variable pH environment, has encouraged the development of novel pH-responsive delivery systems able to protect water-soluble drugs from the harsh GIT environment and deliver high drug payload to the colon for colonic therapies.

Learning Objectives:

  • Demonstrate the applicability of an acrylate-based hydrogel as an inexpensive drug delivery carrier.
  • Understand the effect of gastro-resistant capsules on the pH-responsiveness of hydrogel carriers.
  • Demonstrate the ability of capsule-hydrogel delivery systems for targeted colonic drug delivery.