(457) Efficient Manufacturing of Delayed Release Minitablets using a Seal and Enteric Coating Approach
Introduction: The primary objective of this study was to develop delayed-release omeprazole minitablets using a direct compression method and ensure the stability of drug by applying a sub-coating of instant release polyethylene glycol- polyvinyl alcohol graft copolymer followed by the enteric coating process using methacrylic acid-ethyl acrylate co-polymer (1:1) dispersion using the enteric coating polymer. Co-Author: Nitin Swarnakar
Learning Objectives:
Assess the cost-effectiveness and labor-saving benefits of the algorithm-based model.
Simplify manufacturing complexity by utilizing all-in-one co-processed excipients.
Describe the function of seal coat in minimizing the degradation of acid sensitive omeprazole.
Ming Ji – Scientist, BASF Corporation; Kun Chen – Scientist, BASF Corporation; Ramesh Muttavarapu – Global SME - Technical & Scientific Affairs, Thermo Fisher Scientific; Gyan Mishra – Scientist, Thermo Fisher Scientific; Bhim Gadal – Scientist, Thermo Fisher Scientific; Kavya Muddsani – Scientist, Thermo Fisher Scientific; Sandip Tiwari – Head of Technical Services - Pharma Solutions, BASF Corporation; Nitin Swarnakar - NA Applications Lab Manager - BASF Corporation
