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Oral Delivery (Focus Group - OrD)

(463) Exploring Orodispersible Films Containing the PROTAC ARV-110 in Solvent Casting using PVA

Introduction:

Orodispersible films (ODFs) present an efficient drug delivery system, enhancing patient compliance, cost-effectiveness, and facilitating emergency medication through a non-invasive oral route. This project focuses on formulating ODFs for Proteolysis Targeting Chimera (PROTAC) ARV-110, aiming to improve its solubility. ARV-110 faces significant challenges due to its low solubility, as it exceeds the "Rule of Five" molecular criteria. By enhancing solubility, ODFs pave the way for effective oral delivery of PROTACs [1, 2, 3].

Learning Objectives:

  • evaluate the challenges and solutions in oral delivery systems for poorly soluble APIs like PROTACs.
  • understand methods used to assess the disintegration, dissolution, and mechanical strength of ODFs.