(466) Enabling Oral Delivery of Salmon Calcitonin via SNEDDS: Impact on Protection and Activity
Introduction: Oral peptide delivery is challenging due to enzymatic degradation and poor permeation. One approach to enhance absorption is through Self-nano emulsifying drug delivery systems (SNEDDS). However, incorporating hydrophilic peptides requires prior lipidization through hydrophobic ion pairs (HIP)1. In this study, salmon calcitonin (sCT), a regulator of plasma calcium, was complexed with anionic surfactants (AnS) sodium decanoate (C10) or sodium docusate (SDOCS), loaded into SNEDDS, and evaluated for proteolytic protection and pharmacological activity.
Learning Objectives:
Formulate sCT complexes with oppositely charged AnS.
Assess the protective effect of SNEDDS loaded with sCT:AnS against proteolytic degradation.
Evaluate the pharmacological hypocalcemic activity of sCT formulation after oral gavage of rats.
