(472) Hydrogel-Forming Microneedles For Vancomycin Delivery To Combat Antimicrobial Resistance

Introduction: Antimicrobial resistance (AMR) is a critical global health issue, worsened by antibiotic misuse and challenges in treating multidrug-resistant infections like MRSA [1]. Vancomycin, a first-line therapy, faces limitations in resource-limited settings due to its intravenous administration and storage needs [2]. Factors like needle phobia will lead to poor adherence and exacerbate AMR. This study develops hydrogel-forming microarray patches (HF-MAPs) to optimize vancomycin delivery, enhance adherence, and combat AMR effectively.