(473) Enhancing Therapeutic Efficacy and Immune Response with Bispecific Gold Nanoparticles in Cancer

Introduction: Bispecific antibodies (bsAbs) emerge as new promising cancer immunotherapy, redirecting immune cells to tumors and blocking survival pathways. However, their clinical use faces challenges, including complex design, poor pharmacokinetics, limited stability, and adverse effects in solid tumors' suppressive microenvironments [1]. This study presents a gold nanoparticle (GNP)-based nanoplatform leveraging GNPs' biocompatibility and tunable properties to enhance bsAb therapies [2].