(474) Controlled-Release Surface Coating to Prevent Ventilator-Associated Pneumonia on Endotracheal Tubes

Introduction: While vital for respiration, endotracheal tubes (ETTs) are susceptible to bacterial colonization, often by antibiotic-resistant bacteria, leading to the development of ventilator-associated pneumonia (VAP). VAP is a leading cause of morbidity and mortality in intensive care units, with rates up to 76% depending on patient conditions and pathogens [1,2]. This study proposes a multi-layered ETT coating combining a silver-thiol layer with an adherent HEMA-MMA hydrogel matrix to provide a sustained release profile, reducing infection risk and enhancing patient outcomes.