(477) Characterization of physical properties and design of delivery systems for a chlorin e6 derivative
Introduction: Chlorin e6 and its derivatives are widely used as photosensitizers in photodynamic therapy. We have synthesized a derivative suitable for both transdermal and intravenous formulations. The physicochemical properties of this derivative were studied under various conditions to identify optimal excipient combinations and design effective formulations. These formulations include gel-type systems as well as dispersed nano- and submicron-sized particles in water.
Learning Objectives:
Understand the physicochemical properties of a chlorin e6 derivative for photodynamic therapy.
Analyze the impact of recrystallization solvents on chlorin e6 derivative formulations.
Evaluate tumor-targeting efficacy in chlorin e6-based photodynamic therapy formulations.
