Introduction: Tetracyclines are well-known antibacterial agents used to treat acne vulgaris. They target Propionibacterium acnes and reduce sebum-free fatty acids and extracellular lipase activity (1). However, their hydrophilicity and low log P limit their ability to penetrate the pilosebaceous canal and permeate through the skin (2). This research focuses on developing biocompatible and biodegradable carboxymethyl cellulose (CMC)-based dissolving microneedle array patches (DMAPs) to enhance tetracycline hydrochloride (TTC) skin deposition and improve acne treatment (3).
Learning Objectives:
Examine the characteristics and properties of CMC for the fabrication of dissolving microneedles
Assess the in vitro delivery of TTC via CMC-based DMAPs
Evaluate the effectiveness of DMAPs TTC-loaded against acne-causing bacteria
