(482) Enhancing the storage stability and delivery of extracellular vesicles by using microneedles

Introduction: Stem cell-derived extracellular vesicles (SC-EVs) are nano-sized vesicles that possess biological regenerative effects due to their internal contents, including protein and mRNA, originating from those found in their parent cells [1.2]. While SC-EVs have extensive potential for skin care, their applications are limited because of poor long-term storage stability and insufficient delivery to the dermis layers [3]. In this study, we have developed SC-EVs-loaded dissolving microneedles (EV_MNs) to overcome these limitations.