(489) Impact of quantitative differences in carbomer on drug release from diclofenac sodium topical gels
Introduction: Differences in the formulation composition and/or the manufacturing process, may influence the physicochemical and structural (Q3) properties, and thereby, the performance of topical products. The aim of the current study is to assess the impact of quantitative differences in carbomer on a topical gel’s Q3 properties and performance such as in vitro drug release.
Learning Objectives:
Grasp the impact of quantitative differences in carbomer on Q3 properties of diclofenac sodium gels
Understand how quantitative differences in carbomer affects drug release from diclofenac sodium gels
Khadija Abdulhafid, BPharm, MPharm, MS – PhD Candidate, Center for Dermal Research, Rutgers-The State University of New Jersey; Mengmeng Niu, PhD – Senior Pharmacologist for Topical and Transdermal Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration; Priyanka Ghosh, PhD – Lead Pharmacologist, Office of Research and Standards, U.S. Food and Drug Administration; Bozena Michniak-Kohn, PhD, DSc. (Hons), FAAPS, FRSC, M.R.Pharm.S. – Professor, Center for Dermal Research, Rutgers-The State University of New Jersey
