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Skin and Mucosal Delivery (Focus Group - SMD)

(495) Enhanced Transdermal Permeation of Diclofenac Sodium using Mango Seed Kernel Starch Nanoparticles

Introduction: Limited studies explore Mango Seed Kernel Starch (MSKS) as a drug carrier. Extracted from agro-industrial mango waste, MSKS is cost-effective, readily available, and holds significant potential as a pharmaceutical excipient with various applications. The purpose of this study was to prepare and characterize diclofenac-containing nanoparticles obtained from starch isolated from mango seed kernels and compare the transdermal permeation of the drug-loaded nanoparticles with an ethanolic solution of diclofenac sodium using donated human cadaver skin and Franz diffusion cells.

Learning Objectives:

  • describe the extraction and characterization of Mango Seed Kernel Starch(MSKS).
  • understand the preparation and characterization of drug-loaded MSKS Nanoparticles (MSKSNPs).
  • evaluate the Transdermal Permeation of drug-loaded (MSKSNPs) using human cadaver skin.