(499) Innovations in Hollow Tube Implants for Targeted Drug Delivery Systems
Introduction: Over the past decade, hot melt extrusion (HME) has gained importance in pharmaceutical industry due to its advantages like a solvent-free process, fewer steps, and high reproducibility. HME facilitates continuous manufacturing with excellent content uniformity (1). This study discusses hollow tube implant manufacturing using HME, focusing on critical steps. Subcutaneous implants, usually cylindrical rods, offer controlled API release, enhancing patient compliance. Applications include contraception and chronic disease treatments. Hollow tubes are notable for targeted, sustained drug release.
Learning Objectives:
Mastering Extrusion Process Parameters
Learn the importance of maintaining screw speed and temperature as high as necessary for processing
Learn how the outer diameter of the extruded material is measured using a 1-axis laser measurement
