(500) Unlocking the Potential of Needle-Free Jet Injectors for Intradermal Delivery of Nanoparticles
Introduction: Needle-free jet injectors (NFJIs) utilize high-pressure jets to deliver therapeutics into the intradermal, subcutaneous, or intramuscular layers. They are one of the promising alternative methods to needle-based injections. NFJIs are already in clinical use for vaccination, diabetes, and cosmetic treatments (1). Yet, the applicability of NFJIs to deliver different classes of therapeutics is still in its infancy (2). This study aims to assess the intradermal delivery of nanoparticles with respects to their penetration, distribution, retention in the skin and therapeutic outcomes, using NFJIs.
Learning Objectives:
Evaluate the stability of the nanoparticles after intradermal injection using NFJIs
Evaluate the intradermal delivery efficacy of nanoparticles using conventional needle and NFJIs
Bonan Zhao – PhD candidate, Division of BioTherapeutics, Leiden University; Koen van der Maaden – Assistant Professor, Department of Tumor Immunology, Leiden University Medical Center; Robert Rissmann – Research Director Dermatology, Professor Translational Dematology, Department of Dermatology, Division of BioTherapeutics, Center for Human Drug Research, Leiden University; Matthias Barz – Professor Biotherapeutics Delivery, Division of BioTherapeutics, Department of Dermatology, Leiden University, University Medical Center of the Johannes Gutenberg University Mainz; Heyang Zhang – Researcher Biopharmaceuticals/Postdoc, Division of BioTherapeutics, Leiden University
