(500) Unlocking the Potential of Needle-Free Jet Injectors for Intradermal Delivery of Nanoparticles

Introduction: Needle-free jet injectors (NFJIs) utilize high-pressure jets to deliver therapeutics into the intradermal, subcutaneous, or intramuscular layers. They are one of the promising alternative methods to needle-based injections. NFJIs are already in clinical use for vaccination, diabetes, and cosmetic treatments (1). Yet, the applicability of NFJIs to deliver different classes of therapeutics is still in its infancy (2). This study aims to assess the intradermal delivery of nanoparticles with respects to their penetration, distribution, retention in the skin and therapeutic outcomes, using NFJIs.