(504) An emulsion-based microneedle formulation for transdermal delivery of peptide therapeutics.

Introduction: Polymeric microneedle patches represent a promising platform for transdermal peptide delivery by bypassing first-pass metabolism and eliminating sharp waste. FDA-approved polymers, such as PLGA, are widely used for this purpose (1). Incorporating peptide therapeutics into PLGA microneedles typically involves the use of nanoparticles (2). However, this approach is time-consuming and can result in substantial drug loss, potentially lading to suboptimal peptide loading in the microneedles. This study explores a novel strategy that aims to overcome these challenges during microneedle preparation.