(102-A) Pulmonary Fibrosis Modeling with Tyramine-Modified Silk Hydrogels
Introduction: Lung fibrosis involves excessive extracellular matrix deposition and tissue stiffening, impairing lung function1. In vitro models replicating fibrotic tissue properties are essential for understanding disease mechanisms and testing therapies. Silk fibroin-based hydrogels offer tunable stiffness and biocompatibility, making them ideal for these in vitro models2. This study evaluates the cytocompatibility and fibrotic response of tyramine-modified silk hydrogels using human lung fibroblasts (NHLF).
Learning Objectives:
Understand the importance of hydrogel stiffness on lung fibrosis modeling
Aria Yang – Researcher, Tufts University; Thomas Falcucci – Researcher, Tufts University; Jing-Jie Huang – Researcher, Tufts University; Jugal Sahoo – Researcher, Tufts University; Sabrina Madiedo-Podvrsan – Researcher, Tufts University; David Kaplan – Principal Investigator, Tufts University
