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Nanomedicine and Nanoscale Delivery (Focus Group - NND)

(424-A) Cubic Liquid Crystalline Nanoparticles for Co-Delivery of siRNA and Drugs in Alzheimer's Therapy.

Introduction: Alzheimer’s disease (AD) is a neurological disorder marked by cognitive decline and motor impairment, with origins that remain partially understood [1]. To address the limitations of conventional treatments, this study proposes a combined gene-silencing approach with an anti-inflammatory drug. Cubic liquid crystalline nanoparticles were developed to co-deliver BACE-targeting siRNA and piperine via intravenous administration, focusing on optimizing drug loading and surface properties, including a positive charge and stealth effect.

Learning Objectives:

  • Design of nanoparticles based in liquid crystalline phase to enable co-delivery of siRNA and drug.
  • Improve the co-delivery of therapeutics across Blood Brain Barrier
Maria Vitória Bentley – Full Professor, University of São Paulo