(389) Green Propolis-loaded Lipid Nanostructure Reduce SARS-CoV-2 Replication and Inflammation
Introduction: Brazilian green propolis (GP) is rich in bioactive compounds with antiviral and anti-inflammatory potential, but its clinical use is limited by low stability, poor bioavailability, and strong flavor [1,2]. Encapsulation of GP in lipid nanostructures may overcome these issues by improving delivery and reducing toxicity. Thus, this study evaluated the ability of a green propolis-loaded lipid nanostructure to inhibit SARS-CoV-2 replication and inflammation, supporting its potential as a natural COVID-19 therapy.
Learning Objectives:
Upon completion, participants will be able to describe the formulation process of LN-GP
Upon completion, participants will be able to evaluate the biological effects of LN-GP
Upon completion, participants will understand enhanced efficacy of LN-GP against SARS-CoV-2
Iasmin Ferreira – PhD student, University o São Paulo; Isabela Justino – PhD student, University of São Paulo; Ronaldo Martins – Professor, University of São Paulo; Thais de Lima – student, University of São Paulo; Maria Vitória Souza – student, University of São Paulo; Jairo Bastos – Professor, University of São Paulo
