(422) Self-Assembly of Peptide–Drug Conjugates into Supramolecular Polymers Enhances Immunogenic Cell Death in Glioblastoma Cells

Supramolecular polymers formed by peptide–camptothecin conjugates have emerged as promising platforms in cancer therapy. Here, we investigated the immunogenic cell death (ICD)- inducing capability of Tubustecan 1 (TT1), a self-assembling camptothecin–peptide conjugate, in glioblastoma cells. Previous studies indicated that TT1 shows enhanced therapeutic efficacy when assembled. We hypothesized that the self-assembled supramolecular polymer structure is critical for ICD enhancement.