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Delivery Technologies for Diversified Products

(146) Development of Water-Soluble Functionalized Oligomers with Controlled Bleach Releasing Properties for Long-Term Antiviral Applications

Introduction: Pandemics, such as the recent COVID-19 pandemic, have spread globally and claimed millions of lives. Surface contamination is one primary route that helps and speeds the spread of viruses, especially in public areas. The leading measure includes disinfecting surfaces using small molecules, such as bleach, several times a day. Therefore, there is a need to synthesize new, efficient, and stable disinfectants with controlled release properties to protect these surfaces from viral transmission. Reported research efforts focus on small-molecule-based surface decontamination, including solutions such as bleach and ethanol. In this work, we are focusing on utilizing functional polymers by synthesizing a new class of antiviral oligomers modified with n-halamine and quaternary ammonium functionalities as long-lasting disinfecting materials with controlled and long-term bleach releasing. The most active oligomers demonstrated better antiviral activity compared to household bleach, with over 99.8% effectiveness against SARS-CoV-2 as well as other viruses at far lower concentrations by 60 times. Furthermore, the active materials demonstrated viral deactivation and sustained efficacy against viruses on various surfaces for the long term, while causing no harm to human cells. Thus, these polymers are promising alternatives with controlled and long-term release for effective disinfection in future pandemics, as well as long-lasting for routine use.

Learning Objectives:

  • Combinatorial synthesis of dual functionalized polymers with controlled release properties.
  • Long-lasting disinfecting materials with controllable active chlorine release up to several months.
  • Antiviral polymers against SARS-CoV-2 and seasonal influenza at concentrations far lower than 3% bleach.
Eid Nassar-Marjiyaa,†, Konda Reddy Kundurua,†, Luna Rizika,†, Krishanu Ghosala,†, Nofar Atarib, Michal Mandelboimb,c and Shady Faraha,d,* aThe Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery Technologies, The Wolfson Faculty of Chemical Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel. bCentral Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, 5262000, Israel cDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 6997801, Israel dThe Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.