Industry Session
Tristan Kovačič, n/a
Project Manager
PC4
Sartorius BIA Separations
Ajdovščina, Ajdovscina, Slovenia
Mojca Tajnik Sbaizero, n/a
Head of product-application area
Process development for viral vectors and vaccines
Sartorius BIA Separations
Ajdovscina, Slovenia
The participants will learn about the advantages of using chromatography to analyze and purify LNP drug products. Specifically, the use cases on monolithic columns will be showcased. A PATfix chromatographic system with an LNP analytical platform will be installed and presented and the use of hardware and software demonstrated. Analytical methods will be shown that determine: RNA quantity and quality within LNP drug products, encapsulation efficiency, size distribution, lipid composition, RNA-lipid adducts and lipid quality. An alternative to existing purification methods for LNPs will be introduced.