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Final Program


CRS Abstract Guide

Gene Delivery and Gene Editing
Technical Session

Tech Session II: Gene Delivery and Gene Editing I

Tuesday, July 15, 2025
2:00 PM - 4:00 PM EDT
Location: 119 A

Sponsored By 

Sponsored by: XGen Bio

Delivery of nucleic acids (mRNA, pDNA, oligonucleotides) with nanoformulations, modulation of protein expression, genome editing, vaccination, overcoming biological limitations (e.g., endosomal escape, cellular targeting, biodistribution).

Presentations:

  • 2:02 PM - 2:04 PM EDT
    XGen Introduction

    Presenter: Rui Zhang

  • 2:04 PM - 2:29 PM EDT
    Nature-inspired nanotechnology for RNA delivery to myeloid cells and bone marrow progenitors

    Invited Speaker - Exceptional Abstract: Roy van der Meel, PhD – Eindhoven University of Technology

  • 2:29 PM - 2:54 PM EDT
    Development of SORT lipid nanoparticles (LNPs) for genome correction of disease-causing mutations

    Invited Speaker - Exceptional Abstract: Daniel J. Siegwart, PhD – University of Texas Southwestern Medical Center

  • 2:54 PM - 3:05 PM EDT
    Cardiac-tropic Lipid Nanoparticles Provide Selective Vascularization After Myocardial Infarction

    Oral Abstract Speaker: Junchao Xu (he/him/his) – university of pennsylvania

  • 3:05 PM - 3:16 PM EDT
    Targeting a novel oncogene with an azacitidine-based prodrug nanocarrier to elicit immunogenic cell death for advanced cancer therapy

    Oral Abstract Speaker: Bei Zhang, MS (she/her/hers) – University of Pittsburgh

  • 3:16 PM - 3:27 PM EDT
    One-component Janus dendrimers: a novel platform for efficient mRNA vaccine delivery

    Oral Abstract Speaker: Wook-Jin Park, Ph.D – University of Pennsylvania

  • 3:38 PM - 3:49 PM EDT
    Virus-Mimicking Nanoparticles for Precise Intracellular siRNA Delivery

    Oral Abstract Speaker: Tong Wu, n/a – Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

  • 3:49 PM - 4:00 PM EDT
    Unraveling endosomal escape: mechanistic insights into lipid nanoparticle-mediated RNA delivery

    Local Chapter Speaker: Alice Spadea – MPI-CBG