Thermostabilization of a Model Viral-Vectored Oral Thin Film Vaccine using DoE Approach
Tuesday, July 15, 2025
11:16 AM - 11:27 AM EDT
Location: 119 B
Introduction: Vaccines rely on a global cold chain to maintain vaccine potency throughout the product life cycle. However, 50% of vaccines that are thrown out each year are due to cold chain breaks [1]. Existing vaccine thermostabilization methods like lyophilization and spray-drying impart significant stress on the vaccine, reducing its potency. Therefore, dissolvable oral thin films (OTFs) have emerged as an alternative thermostabilizing vaccine delivery platform wherein the vaccine is immobilized in a polymer-sugar matrix and administered to the oral mucosa.
Learning Objectives:
At the completion of this activity, participants will know
To evaluate the impact of different excipients on retaining viral infectious titer in a solid state
To implement a design of experiment in formulation studies
Iris Wang – Lab Technician, Medicine, McMaster Immunology Research Center, McMaster University; James Mayo – Lab Technician, Chemistry and Chemical Biology, McMaster University; Yva Rasco – Student, Chemistry and Chemical Biology, McMaster University; Grace Lenihan – Student, Chemistry and Chemical Biology, McMaster University; Benjamin Macphail – Chief Scientist, Rapid Dose Therapeutics; Mark Larché – Professor, Medicine, McMaster Immunology Research Center, Firestone Institute for Respiratory Health, The Research Institute of St. Joe's Hamilton, McMaster University; Alex Adronov – Professor, Chemistry and Chemical Biology, Brockhouse Institute for Materials Research, McMaster University
