Injectable devices as cell factory implants for therapeutic antibody production

Introduction: Antibodies have emerged as a leading biotherapeutic class, but their subcutaneous or intravenous administrations is limited by the rate of systemic clearance, necessitating frequent dosing which is inconvenient and costly for patients. A promising approach is the use of encapsulated recombinant cells as a viable source for continuous antibody production. We designed minimally invasive subcutaneous injectable devices to deliver antibody-producing cell factories for sustained antibody delivery from a fixed payload of cells. These macro devices prevent cell escape & can be safely removed.