Isolation and Focal Treatment of Brain Aneurysms using Interfacial Fluid Trapping

Introduction: Current methods for localized intravascular treatments often use solid implants like metallic coils for aneurysm embolization or direct injections of therapeutic agents that can disperse beyond the aneurysms, causing complications (1,2). Thus, it's essential to develop a strategy to ensure precise delivery of injectable therapeutics to the disease site. We present a fluid-based approach utilizing surface tension and immiscible fluid interactions for localized treatment at brain aneurysm sites (3) (Fig. 1).