Inhibition of Tumor Metastasis by Liquid Nitrogen-shocked Tumor Cells with Oncolytic Virus Infection

Oncolytic viruses (OVs) comprise an emerging cancer therapeutic modality involving both direct tumor cell lysis and the induction of immunogenic cell death. Nevertheless, the development of intravenous administration of OVs for a broad scope of tumor foci has been a major challenge over time. Herein, we describe a virus-concealed tumor-targeting strategy enabling OVs delivery toward lung metastasis via systemic administration. Such a Trojan Horse-like vehicle avoids virus neutralization and clearance in the bloodstream and facilitates tumor-targeted delivery.