Nature-inspired nanotechnology for RNA delivery to myeloid cells and bone marrow progenitors
Tuesday, July 15, 2025
2:04 PM – 2:29 PM EDT
Introduction: Nucleic acid therapeutics harbor great potential for silencing, expressing, or editing genes but require sophisticated delivery technology1. Here, I introduce platform nanotechnology based on natural lipoproteins, designed for targeted and intracellular delivery of small interfering RNA (siRNA), antisense oligonucleotides (ASO), and messenger RNA (mRNA) to myeloid cells and hematopoietic stem and progenitor cells (HSPCs) in the bone marrow2.
Learning Objectives:
At the completion of this activity, participants will know
Understand apolipoprotein nanoparticles' ability to deliver RNA to immune cells and progenitors
