Theranostic Targeted pH-sensitive Liposomes for Breast CancerBone Metastasis

Introduction: Liposomes are versatile nanocarriers widely recognized for their ability to be customized for various drug delivery applications, particularly in cancer treatment [1,2]. Bone metastasis in breast cancer is a challenging to treat complication due to poor chemotherapy distribution to the bones [3]. This study developed pH-sensitive, theranostic liposomes to improve drug release in the tumor microenvironment. Paclitaxel serves as the anticancer agent, and IR780 is used as a near-infrared (NIR) imaging probe. Liposomes are also functionalized with alendronate to target bone tissue specifically.