Tech Session II: Nanomedicine and Nanoscale Delivery (Focus: Imaging)
Theranostic Targeted pH-sensitive Liposomes for Breast Cancer Bone Metastasis
Tuesday, July 15, 2025
3:16 PM - 3:27 PM EDT
Location: 121 B/C
Introduction: Liposomes are versatile nanocarriers widely recognized for their ability to be customized for various drug delivery applications, particularly in cancer treatment [1,2]. Bone metastasis in breast cancer is a challenging to treat complication due to poor chemotherapy distribution to the bones [3]. This study developed pH-sensitive, theranostic liposomes to improve drug release in the tumor microenvironment. Paclitaxel serves as the anticancer agent, and IR780 is used as a near-infrared (NIR) imaging probe. Liposomes are also functionalized with alendronate to target bone tissue specifically.
Learning Objectives:
At the completion of this activity, participants will know
Understand how liposomes can be tailored to promote theranostics of breast cancer bone metastasis.
Eliana Martins Lima – Full Professor, Federal University of Goias; Ana Luiza Ribeiro de Souza – Post-Doc, Federal University of Goias; Kimberley S. Samkoe – Associate Professor, Dartmouth College; Samuel S. Streeter – Assistant Professor, Dartmouth
