Auger electron-emitting theranostic micelles for image-guided radio-chemotherapy

Introduction: Radio-nanomedicine (combining nuclear medicine and nanotechnology) is an emerging field in nuclear imaging and therapy.[1] BRCA-mutated triple negative breast cancer is highly aggressive, resistant and prone to metastasis. In this context, combining poly(ADP-ribose) polymerase inhibitors (PARPi) and Auger electron-emitting (Auger-E) radiotherapeutics holds promise.[2] Yet, their effectiveness and translation are hampered by tracer instability and low tumor accumulation. We develop a micelle platform co-delivering Auger-E and SPECT-imageable PARPi for tumor-targeted radio-theranostics (Fig.1A).

Laura Schäffer – PhD Student, RWTH Aachen University Hospital, Department of Nuclear Medicine; Alec Wang – PhD Student, RWTH Aachen University Hospital, Institute for Experimental Molecular Imaging; Alexandru Florea – Dr. Dr. med., RWTH Aachen University Hospital, Department of Nuclear Medicine; Elea Henrard – Student, RWTH Aachen University Hospital, Department of Nuclear Medicine; Zheran Lu – PhD Student, RWTH Aachen University Hospital, Department of Nuclear Medicine; Eva Buhl – Dr. rer. nat, Electron Microscopy Facility, Institute of Pathology, RWTH Aachen University Hospital; Marcus Frings – PhD Student, Institute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany; Carsten Bolm – Professor, Institute of Organic Chemistry, RWTH Aachen University; Felix Mottaghy – Professor, RWTH Aachen University Hospital, Department of Nuclear Medicine; and Maastricht University Medical Center, Department of Radiology and Nuclear Medicine; Twan Lammers – Professor, RWTH Aachen University Hospital, Institute for Experimental Molecular Imaging; Agnieszka Morgenroth – Dr. Dipl.-Biol., RWTH Aachen University Hospital, Department of Nuclear Medicine