Tech Session II: Nanomedicine and Nanoscale Delivery (Focus: Imaging)
Auger electron-emitting theranostic micelles for image-guided radio-chemotherapy
Tuesday, July 15, 2025
3:49 PM – 4:00 PM EDT
Introduction: Radio-nanomedicine (combining nuclear medicine and nanotechnology) is an emerging field in nuclear imaging and therapy.[1] BRCA-mutated triple negative breast cancer is highly aggressive, resistant and prone to metastasis. In this context, combining poly(ADP-ribose) polymerase inhibitors (PARPi) and Auger electron-emitting (Auger-E) radiotherapeutics holds promise.[2] Yet, their effectiveness and translation are hampered by tracer instability and low tumor accumulation. We develop a micelle platform co-delivering Auger-E and SPECT-imageable PARPi for tumor-targeted radio-theranostics (Fig.1A).
Learning Objectives:
At the completion of this activity, participants will know
Assess the potential of Auger electron emitting-based radio-nanomedicines for (BRCA-mutated) cancers
Evaluate the relevance of nuclear imaging in tumor-targeted and image-guided radio-chemotherapy
Describe the impact of nanomedicine-based co-delivery for PARP-targeted radionuclide theranostics
