Thermo-reactive In-situ forming Liposome Depot (TILD): From computational design to in-vivo efficacy

Introduction: Frequent drug administrations burden patients and caregivers, leading to poor adherence and suboptimal outcomes, particularly in geriatric, incapacitated, and veterinary populations.[1-2] In veterinary medicine, effective pain management often requires complex treatment schemes, causing distress for animals and strain for pet owners.[1] To address these challenges, we developed TILD, a temperature-triggered liposomal delivery system forming depots in the subcutaneous space. TILD enables sustained drug release over several days and significantly enhancing patient comfort and treatment efficacy.

Simone Aleandri, PhD – Senior Scientist in Drug delivery sciences, University of Bern, Switzerland; Davide Bochicchio, PhD – Senior Scientist in molecular dynamics simulations, University of Genova, Italy; Belinda Haemmerle, Mag. med. vet. – Veterinary doctor for companion animals, Clinic for Companion animals, VetTrust Clinic Basel, Switzerland; Laura Baraldi, PhD – Post Doc, Laboratory of Food and Soft Materials, ETH Zürich, Switzerland; Stefan Schürch, Prof. Dr. – Professor in Chemical Analytics, University of Bern, Switzerland; Martina Vermathen, PhD – Senior Scientist in NMR analytics, University of Bern, Switzerland; Peter Vermathen, Prof. Dr. – Magnetic Resonance in Medicine, University Hospital, University of Bern, Switzerland; Raffaele Mezzenga, Prof. Dr. – Group head Food and Soft Materials, ETH Zurich, Switzerland; Giulia Rossi, Ass. Prof. Dr. – Ass. professor in Molecular dynamics simulations, University of Genova, Italy; Alessandra Bergadano, PD, DVM, Dr.Med.Vet., Dip.ECVAA, Dip. ECLAM, PhD – Head of Experimental Animal Center, Experimental Animal Center, University of Bern, Switzerland; Paola Luciani, Prof. Dr. – Professor in Pharmaceutical technology, University of Bern, Switzerland