Tech Session III: Nanomedicine and Nanoscale Delivery (Bioengineering)
Chiral Quantum Dots Enhanced Small Extracellular Vesicles for Gene Delivery
Wednesday, July 16, 2025
11:16 AM – 11:27 AM EDT
Introduction: Small extracellular vesicles (sEVs) are promising platforms for drug delivery due to their natural targeting abilities, biocompatibility, and low immunogenicity. Despite advancements, challenges persist in efficient cargo loading, targeted delivery, and intracellular release. This work provides insights from our current studies: (1) investigating sEVs cell-of-origin-dependent uptake and cargo release mechanisms; and based upon the finding from the uptake study, (2) we developed pH-responsive, chiral graphene quantum dot (GQD)-functionalized sEVs for enhanced siRNA delivery to breast cancer.
Learning Objectives:
At the completion of this activity, participants will know
Upon completion, participant will be able to demonstrate sEV uptake mechanism.
Upon completion, participant will be able to demonstrate a novel sEV drug loading strategy.
Upon completion, participant will be able to demonstrate an enhanced sEV gene delivery strategy.
